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  • Pharmacology Like other benzodiazepines, clonazepam is believed to act by simulating the action of GABA on the central nervous system. Because of strong anxiolytic properties and euphoric side-effects it is said to be among the class of 'highly potent' benzodiazepines. Although benzodiazepines are valuable in the treatment of anxiety disorders, they have some potential for misuse and may cause dependence or addiction. The sedative effects of clonazepam are relatively weak, manifestations of severe central nervous system depression are rare, as well as when compared to most other benzodiazepines. One milligram of clonazepam is approximately equivalent to twenty milligrams of diazepam. [1] Unlike most other benzodiazepines clonazepam appears to also have a secondary effect on the neurotransmitter serotonin. [2]. It has shown itself to be useful as a short-term adjunct to SSRI treatment in Clinical Depression [3], with some other anxiety disorders, but the role of the serotonergic Epilepsy do not develop a tolerance, and do not need increasingly large the disorder, reducing the startle response in sufferers. Those who fall when startled are less likely to do so once treated. Anxiety disorders. Due to the chronic nature of anxiety, long-term low-dose Indications benzodiazepine action. treatment may be necessary for some Recreational Use patients; this continuation of treatment should not be Panic attacks Restless leg syndrome (RLS) Initial treatment of mania, together with firstline-drugs such as lithium, haloperidol or risperidone Hyperekplexia. Clonazepam is prescribed to dampen the effects of Hallucinogen persisting perception disorder (off-label use) Chronic fatigue syndrome Night terrors Tourette Syndrome - Clonazepam has shown to be in 1997 and is now manufactured and marketed by several associated with TS, though is still considered an off-label usage by many. Schizophrenia - Clonazepam has been prescribed in order to alleviate the side effects of certain antipsychotic agents used in the treatment of Schizophrenia. Impaired motor function doses to experience the anxiolytic side effects of the drug. Clonazepam is rarely used as a treatment for insomnia, O'Brien, CP. "Benzodiazepine use, abuse, and dependence", because its sedative effects are relatively weak compared to other benzodiazepines. Availability Klonopin 0.5mg Klonopin 1mg Clonazepam 1mg (Generic) by the slang term "clammies", "Klonnies", Clonazepam was approved in the United States as a generic drug superior to SSRI treatment alone. Similar results have been found companies. Clonazepam is available in the U.S. as tablets (0.5, 1.0, and 2mg), orally-disintegrating tablets (wafers) (0.125, 0.25, 0.5, 1.0, and 2 mg), liquid solution (2.5mg per ml) and for injection (1mg per ml) Side effects Common: Impairment of cognition and judgement Drowsiness Impaired coordination Impaired balance Dizziness Anterograde amnesia (common with higher doses) Rare: Paradoxical Disinhibition[1] (Most frequently in children, the elderly, and in persons with developmental helpful in reducing and dealing with the physical motor tics when compared to its strong anxiolytic and anticonvulsant effects, disabilities) Excitement Irritability Impulsivity Some users report hangover-like symptoms of being drowsy, having a headache, being sluggish, and irritable after waking up if the medication is taken before sleep. This is likely the result of the medication's long half-life which continues to affect the user after they wake up as well as its disruption of the REM cycle. Withdrawal-related: effects enhancing the action of the SSRI treatment remains unclear Anxiety, irritability, insomnia Panic attacks, tremor Seizures similar to delirium tremens (With long-term use of excessive Use of alcohol or other CNS depressants while taking clonazepam greatly intensifies the effects in these cases due to clonazepam's primary anxiolytic mechanism of (and side effects) of the drug. Side effects of the drug itself are generally benign, but sudden withdrawal after long-term use can cause severe, even fatal symptoms. Interactions Similar to Diazepam. An individual who has consumed too much clonazepam will display one or Obsessive Compulsive Disorder,[4] with the combination being doses) more of the following symptoms: Somnolence (difficulty staying awake) Mental confusion Hypotension Impaired motor functions Impaired reflexes Impaired coordination Overdose Impaired balance Dizziness Coma Unless combined with other drugs, deep coma or other and and the mortality rate associated with poisoning is very low. As with other benzodiazepines, overdose symptoms of clonazepam may Clonazepam is commonly prescribed for: be reversed with flumazenil (Romazicon®). Rage Benzodiazapines such as Clonazepam are sometimes used considered abuse or addiction. recreationally, when used for this function they are often referred to or "Kpins" if in Klonopin form, most commonly as a secondary drug to increase the pleasure resulting from a primary drug, or possibly to lessen or prevent some of the primary drug's negative side effects. It should be noted that relatively few cases of addiction arise from legitimate use of benzodiazepines. [5] Up to 30% of individuals treated on a long-term basis develop a form of dependence known as "low-dose-dependence". These patients References Journal of Clinical Psychiatry. 2005;66 Suppl 2:28-33. [6] Wallace, Christina. "Kpin, a hit drug with teens, can be deadly, officials say." Boston Metro, Wednesday April 12, 2006. Page 2.

So... Why?

Pharmacology Like other benzodiazepines, clonazepam is believed to act by simulating the action of GABA on the central nervous system. Because of strong anxiolytic properties and euphoric side-effects it is said to be among the class of 'highly potent' benzodiazepines. Although benzodiazepines are valuable in the treatment of anxiety disorders, they have some potential for misuse and may cause dependence or addiction. The sedative effects of clonazepam are relatively weak, manifestations of severe central nervous system depression are rare, as well as when

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